Buy 5F-ADB


5F-ADB je syntetický kanabinoid na báze indazolu z rodiny indazol-3-karboxamidu,
ktorý sa používal ako aktívna zložka v syntetických výrobkoch z kanabisu a bol predávaný
online ako dizajnérska droga. 5F-ADB je silný agonista receptora CB3, hoci nie je jasné, či je pre tento cieľ selektívny.


N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-3-methyl-D-valine methyl ester (5F-ADB) is one of the most potent synthetic cannabinoids and elicits severe psychotic symptoms in humans, sometimes causing death.

To investigate the neuronal mechanisms underlying its toxicity, we examined the effects of 5F-ADB on midbrain dopaminergic and serotonergic systems, which modulate various basic brain functions such as those in reward-related behavior. 5F-ADB-induced changes in spontaneous firing activity of dopaminergic and serotonergic neurons were recorded by ex vivo electrophysiological techniques.

In dopaminergic neurons, 5F-ADB (1 μM) significantly increased the spontaneous firing rate, while 5F-ADB failed to activate dopaminergic neurons in the presence of the CB1 antagonist AM251 (1 μM). However, the same concentration of 5F-ADB did not affect serotonergic-neuron activity. These results suggest that 5F-ADB activates local CB1 receptors and potentiates midbrain dopaminergic systems with no direct effects on midbrain serotonergic systems.


100 gram, 1000 gram, 200 gram, 2000 gram, 250 gram, 300 gram, 50 gram, 500 gram, 5000 gram

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