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What is Keytruda ?
Keytruda (pembrolizumab) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Keytruda is used to treat:
- advanced skin cancer (melanoma);
- a certain type of non-small cell lung cancer, if your tumor tests positive for “PD-L1”;
- head and neck cancer;
- classical Hodgkin lymphoma in adults and children;
- primary mediastinal large B-cell lymphoma;
- a certain type of bladder and urinary tract cancer;
- a type of cancer that laboratory testing proves to be a microsatellite instability-high or a mismatch repair deficiency solid tumor;
- a certain type of cervical cancer if your tumor tests positive for “PD-L1”; or
- advanced stomach cancer if your tumor tests positive for “PD-L1” and has a specific genetic marker (an abnormal “HER2/neu” gene).
Keytruda is often given when the cancer has spread to other parts of the body, or cannot be surgically removed, or has come back after prior treatment.
Keytruda was approved by the US Food and Drug Administration (FDA) on an “accelerated” basis to treat some types of cancer. In clinical studies, tumors responded to this medicine. However, it has not been shown that Keytruda can improve symptoms or lengthen survival time.
Keytruda can change the way your immune system works, which may cause certain side effects that can lead to serious medical problems.
Keytruda can cause side effects in many different parts of your body. Some side effects may need to be treated with other medicine, and your cancer treatments may be delayed. You will need frequent medical tests to help your doctor determine if it is safe for you to keep receiving Keytruda.
Call your doctor at once if you have: chest pain, cough, shortness of breath, severe muscle pain or weakness, diarrhea and severe stomach pain, blood in your stools, bruising or bleeding, dark urine, yellowing of the skin or eyes, a hormonal disorder (frequent headaches, feeling light-headed, rapid heartbeats, a deeper voice, increased thirst or urination, feeling cold, weight gain or loss), or a change in the amount or color of your urine.
Before taking this medicine
Tell your doctor if you have ever had:
- a lung disease or a breathing disorder;
- liver or kidney disease;
- diabetes, or a thyroid disorder;
- an autoimmune disorder such as lupus, Crohn’s disease, or ulcerative colitis; or
- an organ transplant or stem cell transplant.
Do not use Keytruda if you are pregnant. Pembrolizumab could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose. Tell your doctor right away if you become pregnant.
You should not breast-feed while using pembrolizumab, and for at least 4 months after your last dose.